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PECAM1 Mouse anti-Human, Clone: OTI2E4, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA504812

Catalog No. 50-167-5421


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Description

Description

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. The N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. Further, CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. CD31 is one of key regulatory molecules in the vascular system. CD31 induces susceptibility to atherosclerosis and this cell adhesion molecule is required for leukocyte migration under most inflammatory conditions. Antibodies to CD31 is of value in the study of benign and maligt vascular tumors.
Specifications

Specifications

PECAM1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P16284
CD31, CD31/EndoCAM, GPIIA′, PECA1, PECAM-1, endoCAM
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5175
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI2E4
Unconjugated
PECAM1
Liquid
PECAM1
Full length human recombit protein of human PECAM1 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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