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Pellino 1 Mouse anti-Human, Clone: OTI10D1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526914
DescriptionThe Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|E3 ubiquitin-protein ligase pellino homolog 1, pellino-1, pellino-related intracellular-signaling molecule, protein pellino homolog 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 1-245 of PELI1 produced in E.coli|
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