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Pellino 1 Mouse anti-Human, Clone: OTI10D1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526914

Catalog No. PIMA526914



Description

Description

The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
Specifications

Specifications

Pellino 1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q96FA3
E3 ubiquitin-protein ligase pellino homolog 1, pellino-1, pellino-related intracellular-signaling molecule, protein pellino homolog 1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
57162
Immunohistochemistry (Paraffin), Western Blot
OTI10D1
Unconjugated
PELI1
Liquid
PELI1
Human recombit protein fragment corresponding to amino acids 1-245 of PELI1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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