Invitrogen™ Pericentrin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5116926

Catalog No. PIPA5116926

Description

Positive Samples: SH-SY5Y, Rat heart Immunogen sequence: GEKREDLEQL QQKQVNDHPP EQCGMFTVSD HPPEQHGMFT VGDHPPEQRG MFTVSDHPPE QHGMFTVSDH PPEQRGMFTI SDHQPEQRGM FTVSDHTPEQ RGIFTISDHP AEQRGMFT.

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

Specifications

• Antigen: Pericentrin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCNT
• Gene Alias: AW476095; C86676; KEN; kendrin; KIAA0402; m239Asp; m275Asp; MOPD2; PCN; Pcnt; PCNT2; PCNTB; PCTN2; Pericentrin; pericentrin (kendrin); pericentrin 2; pericentrin-2; pericentrin-250; pericentrin-360; pericentrin-380; pericentrin-B; SCKL4
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 309692, 5116
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.69 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O95613
• Gene Symbols: PCNT
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 95-212 of human PCNT (NP_0060223).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG