Periostin Mouse anti-Human, Clone: OTI2B2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526675
DescriptionPeriostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Fasciclin-I like;MGC119510;MGC119511;OSF 2;OSF-2;OSF2;Osteoblast specific factor 2 (fasciclin I like);osteoblast specific factor 2 (fasciclin I-like);Osteoblast specific factor 2;Osteoblast specific factor;Osteoblast-specific factor 2;PDLPOSTN;Periodontal ligament specific periostin;Periostin;Periostin isoform thy2;Periostin isoform thy4;Periostin isoform thy6;Periostin isoform thy8;Periostin osteoblast specific factor;PN;POSTN;POSTN_HUMAN;RP11 412K4.1;|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 538-781 of POSTN produced in E.coli|
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