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PEX5 Mouse anti-Canine, Human, Non-human primate, Rat, Clone: OTI6E9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525177

Catalog No. PIMA525177


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Description

Description

Peroxisomes are single-membrane bound organelles present in virtually all eukaryotic cells. They are involved in numerous catabolic and anabolic pathways, including beta-oxidation of very long chain fatty acids, metabolism of hydrogen peroxide, plasmalogen biosynthesis, and bile acid synthesis. The Peroxin gene family, which includes more than 20 members, is required for peroxisome biogenesis. Two members of this family, Peroxin 5 (Pex5) and Peroxin 7 (Pex7), are receptors for proteins that contain the peroxisome targeting signal 1 (PTS1) and 2 (PTS2), respectively, and shuttle these proteins from the cytosol to the peroxisome. Peroxin 5, also designated PTS1 receptor, is expressed as two isoforms, Pex5L and Pex5S. Pex5L transports PTS1 and Pex7-PTS2 cargo complexes to the initial Pex5 docking site, Pex14, while Pex5S transports only PTS1 cargoes. Pex5 and Pex7 also require either direct or indirect interaction with Peroxin 13 (Pex13) for proper import into peroxisomes. Mutations in the Peroxin genes result in peroxisome biogenesis disorders (PBDs). Defects in the Pex5 gene are linked to Zellweger syndrome (cerebro-hapato-renal syndrome) of complementation group 2 (CG2), the most severe form of PBDs. Zellweger syndrome is characterized by abnormal neuronal migration in the central nervous system and severe neurologic dysfunction, which leads to early death.
Specifications

Specifications

PEX5
Monoclonal
0.57 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q2M2R8, P50542
Peroxin 5; Peroxin-5; Peroxisomal biogenesis factor 5; Peroxisomal C terminal targeting signal import receptor; Peroxisomal C-terminal targeting signal import receptor; Peroxisomal targeting signal 1 receptor; Peroxisome receptor 1; pex5; PEX5_HUMAN; PTS1 BP; PTS1 receptor; PTS1-BP; PTS1R; PXR1;
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
312703, 486710, 5830, 715173
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
OTI6E9
Unconjugated
PEX5
Liquid
Pex5
Full length human recombit protein of PEX5 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Non-human primate, Rat
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