Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Benzenoids
  6. Benzene and substituted derivatives
  7. Hydroxybenzoic Acid Derivatives
  8. PF 04418948, Tocris Bioscience™

PF 04418948, Tocris Bioscience™

Catalog No. p-4816735
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective EP2 receptor antagonist

Potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).

Chemical Identifiers

CAS 1078166-57-0
Molecular Formula C23H20FNO5
Molecular Weight (g/mol) 409.413
InChI Key LWJGMYMNSNVCEM-UHFFFAOYSA-N
Synonym unii-i7z38e70vf, d0s5ef, prostaglandin e2 ep2 subtype antagonist endometriosis , pfizer, 1-4-fluorobenzoyl-3-6-methoxynaphthalen-2-yl oxymethyl azetidine-3-carboxylic acid, 1-4-fluorobenzoyl-3-6-methoxy-2-naphthalenyl oxy methyl-3-azetidinecarboxylic acid, 1-4-fluorobenzoyl-3-6-methoxy-2-naphthyl oxy methyl azetidine-3-carboxylic acid, 3-azetidinecarboxylic acid, 1-4-fluorobenzoyl-3-6-methoxy-2-naphthalenyl oxy methyl
PubChem CID 25114442
IUPAC Name 1-(4-fluorobenzoyl)-3-[(6-methoxynaphthalen-2-yl)oxymethyl]azetidine-3-carboxylic acid
SMILES COC1=CC2=C(C=C1)C=C(C=C2)OCC3(CN(C3)C(=O)C4=CC=C(C=C4)F)C(=O)O

Specifications

Quantity 10 mg
Formula Weight 409.41
Percent Purity 98%
Chemical Name or Material PF 04418948

Safety and Handling

Recommended Storage Store at -20°C
Provide Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.