PF 04691502, Tocris Bioscience
Potent and selective dual PI 3-K/mTOR inhibitor
Manufacturer: Tocris Bioscience 4820/25
DescriptionPotent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, γ, β, and mTOR, respectively). Displays no significant inhibitory activity at more than 80 protein kinases (concentration ≥ 10 μM) including hVps34, PI 3-K downstream kinases, and MAPK family members. Orally available. Induces robust cell cycle arrest at the G1 phase in U87MG cancer cells and antitumor activity in SKOV3 ovarian cancer xenograft models.
|Observed MW: 425.48|
Safety and Handling
Recommended Storage : Store at -20°C
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