PF 04691502, Tocris Bioscience™

Potent and selective dual PI 3-K/mTOR inhibitor

Manufacturer:  Tocris Bioscience 4820/25

Catalog No. 48-202-5

Description

Potent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, γ, β, and mTOR, respectively). Displays no significant inhibitory activity at more than 80 protein kinases (concentration ≥ 10 μM) including hVps34, PI 3-K downstream kinases, and MAPK family members. Orally available. Induces robust cell cycle arrest at the G1 phase in U87MG cancer cells and antitumor activity in SKOV3 ovarian cancer xenograft models.

Specifications

• Chemical Name or Material: 2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one
• Assay Percent Range: >98%
• Formula Weight: Observed MW: 425.48

• CAS: 1013101-36-4
• Molecular Formula: C₂₂H₂₇N₅O₄
• Quantity: 25mg

Safety and Handling

Recommended Storage : Store at -20°C