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PF 04691502, Tocris Bioscience™
Potent and selective dual PI 3-K/mTOR inhibitor
Supplier: R&D Systems 4820/5
This item is not returnable.
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Description
PF 04691502 is a potent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, γ, β, and mTOR, respectively). Displays no significant inhibitory activity at more than 80 protein kinases (concentration ≥ 10 μM) including hVps34, PI 3-K downstream kinases, and MAPK family members. Orally bioavailable. Induces robust cell cycle arrest at the G1 phase in U87MG cancer cells and antitumor activity in SKOV3 ovarian cancer xenograft models.Specifications
| 2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one | |
| >98% | |
| C22H27N5O4 |
| 1013101-36-4 | |
| 5 mg | |
| Observed MW: 425.48 |
Safety and Handling
Recommended Storage : Store at -20°C
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