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PF 05212384, Tocris Bioscience™

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Quantity:
10mg
This item is not returnable. View return policy
1197160-78-3
C32H41N9O4
615.739
DWZAEMINVBZMHQ-UHFFFAOYSA-N
gedatolisib,1-4-4-dimethylamino piperidine-1-carbonyl phenyl-3-4-4,6-dimorpholino-1,3,5-triazin-2-yl phenyl urea,unii-96265tnh2r,n-4-4-dimethylamino-1-piperidinyl carbonyl phenyl-n'-4-4,6-di 4-morpholinyl-1,3,5-triazin-2-yl phenyl urea,gedatolisib pf-05212384, pki-587,gedatolisib usan:inn,pubchem19144,gedatolisib pki-587,gedatolisib usan/inn
44516953
1-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6
This item is not returnable. View return policy
1197160-78-3
C32H41N9O4
615.739
DWZAEMINVBZMHQ-UHFFFAOYSA-N
gedatolisib,1-4-4-dimethylamino piperidine-1-carbonyl phenyl-3-4-4,6-dimorpholino-1,3,5-triazin-2-yl phenyl urea,unii-96265tnh2r,n-4-4-dimethylamino-1-piperidinyl carbonyl phenyl-n'-4-4,6-di 4-morpholinyl-1,3,5-triazin-2-yl phenyl urea,gedatolisib pf-05212384, pki-587,gedatolisib usan:inn,pubchem19144,gedatolisib pki-587,gedatolisib usan/inn
44516953
1-[4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl]-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6

Potent and selective dual PI 3-K/mTOR inhibitor

Potent and selective dual inhibitor of PI 3-kinase/mTOR (IC50 values are 0.4, 1.6 and 5.4 nM for PI 3-Kα, mTOR and PI 3-Kγ respectively). Exhibits selectivity over 234 other protein kinases (IC50 >10 μM). Potently inhibits tumor cell growth in 37 different tumor cell lines (IC50 < 100 nM). Also exhibits antitumor activity in MDA-361, HCT-116, H1975 and U87MG xenograft models.
Quantity 10mg
Formula Weight 615.73
Percent Purity >98%
Chemical Name or Material PF 05212384

Recommended Storage : Store at -20°C