Tocris™ PF 5274857 hydrochloride

High affinity and selective Smoothened (Smo) receptor antagonist

Manufacturer: Tocris™ 5262/10

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Catalog No. 52-621-0

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For Research Use Only


    Inhibitors PF 5274857 hydrochloride
    Purity >98
    Molecular Weight 473.42
    Quantity 10mg
    Product Type PF 5274857 hydrochloride

    High affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant.

    • Chemical Name: 1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride
    • Formula: C20H25ClN4O3S.HCl
    • CAS Number: 1613439-62-5
    • Solubility: Soluble to 100mM in water and to 100mM in DMSO
    • Purity: >98

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