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Tocris Bioscience™ PF 543 hydrochloride Available on GSA/VA Contract for Federal Government customers only.

Potent and selective SphK1 inhibitor

$209.00 - $835.50

Specifications

Chemical Name or Material (2R)-1-[[(4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol hydrochloride
Molecular Formula C27H31NO4S.HCl
CAS 1706522-79-3
Product Type Target: Sphingosine Kinase Inhibitors
Formula Weight 502.07
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
575410 Available on GSA/VA Contract for Federal Government customers only. View Documents Tocris Bioscience™
5754/10
10mg Each for $209.00
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575450 View Documents Tocris Bioscience™
5754/50
50mg Each for $835.50
Add to cart
 
Description

Description

Potent and selective SphK1 inhibitor (IC50 = 2 nM; Ki = 3.6 nM). Exhibits >100-fold selectivity for Sphk1 over Sphk2. Also exhibits >5,000 fold selectivity over S1P1-5 receptors and 48 protein and lipid kinases. Attenuates proliferation and induces necrosis in human colorectal cancer cells in vitro. Suppresses HCT-116 tumor xenograft growth in mice.

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Specifications

Specifications

(2R)-1-[[(4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol hydrochloride
1706522-79-3
502.07
C27H31NO4S.HCl
Target: Sphingosine Kinase Inhibitors
Safety and Handling

Safety and Handling

Recommended Storage : Desiccate at RT

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