PHD1 Mouse anti-Human, Clone: OTI7H3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527026
DescriptionProlyl hydroxylase domain proteins HIF PHD1, HIF PHD2 and HIF PHD3 (known as PHD1, PHD2 and PHD3 in rodents, respectively) can hydroxylate HIF-alpha subunits. Hypoxia-inducible factor (HIF) is a transcriptional regulator important in several aspects of oxygen homeostasis. The prolyl hydroxylases catalyze the posttranslational formation of 4-hydroxyproline in HIF-alpha proteins. HIF PHD1, which is widely expressed, with highest levels of expression in testis, functions as a cellular oxygen sensor and is important in cell growth regulation. HIF PHD1 can localize to the nucleus or the cytoplasm and is also detected in hormone responsive tissues, such as normal and cancerous mammary, ovarian and prostate epithelium. HIF PHD1 is encoded by EGLN2, which maps to chromosome 19q13.3.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1; HIF-prolyl hydroxylase 1; egl nine homolog 2; estrogen-induced tag 6; hypoxia-inducible factor prolyl hydroxylase 1; prolyl hydroxylase domain-containing protein 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of EGLN2 produced in E.coli|
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