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PHLDA1 Mouse anti-Human, Clone: OTI4D9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527376

Catalog No. PIMA527376


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Description

Description

Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation.
Specifications

Specifications

PHLDA1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q8WV24
Pleckstrin homology-like domain family A member 1, Apoptosis-associated nuclear protein, Proline- and glutamine-rich protein, PQ-rich protein, PQR protein, Proline- and histidine-rich protein, T-cell death-associated gene 51 protein, PHLDA1, PHRIP, TDAG51
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
22822
Western Blot
OTI4D9
Unconjugated
PHLDA1
Liquid
PHLDA1
Human recombit protein fragment corresponding to amino acids 183-401 of PHLDA1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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