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PHLPP Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 227891AP

Catalog No. 50-173-3946


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Description

Description

PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
Specifications

Specifications

PHLPP
0.57 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O60346, Q8CHE4
hSCOP, KIAA0606, PHLPP, PHLPP1, PLEKHE1, SCOP
Rabbit
IgG
150 μL
-20°C
Primary
23239, 98432
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
PHLPP1
Liquid
Phlpp1
PHLPP Fusion Protein Ag18794
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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