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PHLPP1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550475

Catalog No. PA550475


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Description

Description

The antibody detects endogenous levels of total PHLPP1 protein.

PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
Specifications

Specifications

PHLPP1
Polyclonal
Unconjugated
PHLPP1
Liquid
PHLPP1
Fusion protein corresponding to residues near the C terminal of human PH domain and leucine rich repeat protein phosphatase 1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
2.1 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
O60346
KIAA0606, PHLPP, PLEKHE1, SCOP
Rabbit
IgG
100 μL
-20°C
Primary
23239
Documents
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