PHLPPL Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 252441AP
DescriptionProtein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on ft.Ser-473 ft. of AKT1, ft.Ser-660 ft. of PRKCB isoform beta-II and ft.Ser-657 ft. of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ft.Ser-473 ft. of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on ft.Thr-387 ft. leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|KIAA0931, PHLPP like, PHLPP2, PHLPPL|
|23035, 244650, 498949|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|PHLPPL Fusion Protein Ag19000|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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