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PHLPPL Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 252441AP

Catalog No. 50-173-4811


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Description

Description

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on  ft.Ser-473 ft. of AKT1,  ft.Ser-660 ft. of PRKCB isoform beta-II and  ft.Ser-657 ft. of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of  ft.Ser-473 ft. of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on  ft.Thr-387 ft. leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity.
Specifications

Specifications

PHLPPL
0.32 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q6ZVD8, Q8BXA7
KIAA0931, PHLPP like, PHLPP2, PHLPPL
Rabbit
IgG
150 μL
-20°C
Primary
23035, 244650, 498949
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
PHLPP2
Liquid
Phlpp2
PHLPPL Fusion Protein Ag19000
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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