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Phospho-AKT1/AKT3 (Tyr437, Tyr434) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540162

Catalog No. PA540162


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at  ft.Ser-50 ft. negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.
Specifications

Specifications

Phospho-AKT1/AKT3 (Tyr437, Tyr434)
Polyclonal
Unconjugated
AKT3
Liquid
AKT1, AKT3
Peptide sequence around phosphorylation site of tyrosine 437 (T-R-Y(p)-F-D) derived from Human AKT1/3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P31749, Q9Y243
EC 2.7.11.1; RAC-PK-alpha; Protein kinase B; PKB; C-AKT
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10000, 207
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