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Phospho-AKT1 (Ser473) Monoclonal Antibody (SDRNR), PE-Cyanine7, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
$412.65
Specifications
| Antigen | Phospho-AKT1 (Ser473) |
|---|---|
| Clone | SDRNR |
| Concentration | 5 μL/Test |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
25971542
|
Invitrogen
25971542 |
100 Tests |
Each of 1
for $412.65
Save 4% Reg : |
|
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Description
Description: This SDRNR monoclonal antibody recognizes human and mouse AKT (also known as Protein Kinase B (PKB)) when phosphorylated on S473. AKT is a serine/threonine protein kinase that plays a key role in multiple cellular processes including metabolism, proliferation, apoptosis/survival, and migration. There are three homologous isoforms of AKT: AKT1, AKT2, and AKT3. AKT is activated by binding of its pleckstrin homology (PH) domain to membrane phospholipids and by phosphorylation. Phosphorylation of AKT at T308 by PDK1 and at S473 is required for full activation of this kinase. AKT promotes cell survival by inhibiting apoptosis via phosphorylation and inactivation of several targets including Bad, Foxo1, c-Raf, and caspase-9. Deregulation of AKT has been implicated as a major contributing factor in many types of cancer. AKT is negatively regulated by the phosphatase PTEN as well as by the chemical inhibitor LY294002. Specificity of this SDRNR clone was determined by ELISA, flow cytometry, and western blotting. Applications Reported: This SDRNR antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This SDRNR antibody has been pre-titrated and tested by intracellular staining followed by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.06 μg) per test.
Phospho-AKT1 (Ser473) Monoclonal antibody specifically detects Phospho-AKT1 (Ser473) in Human, Mouse samples. It is validated for Flow Cytometry.Specifications
| Phospho-AKT1 (Ser473) | |
| 5 μL/Test | |
| Monoclonal | |
| Liquid | |
| RUO | |
| 11651, 207 | |
| Primary | |
| 4° C, store in dark, DO NOT FREEZE! | |
| AKT1 |
| SDRNR | |
| Flow Cytometry | |
| PE-Cyanine7 | |
| Mouse | |
| Human, Mouse | |
| IgG2a κ | |
| Affinity chromatography | |
| Antibody |
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