Phospho-ALK (Tyr672, Tyr1278) Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA564801
Phospho-ALK (Tyr672, Tyr1278) Polyclonal Antibody detects endogenous levels of ALK only when phosphorylated at Tyr672, Tyr1278.The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3 ft. half of ALK, derived from chromosome 2, is fused to the 5 ft. portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
|Phospho-ALK (Tyr672, Tyr1278)|
|A synthesized peptide derived from human LTK/ALK (Phospho-Tyr672/Tyr1278)|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.4|
|ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246; CD246 antigen; mutant anaplastic lymphoma kinase; NBLST3; TFG/ALK|