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Phospho-ALK (Tyr672, Tyr1278) Rabbit anti-Human, Polyclonal, Invitrogen™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA564801

Catalog No. PIPA564801


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Description

Description

Phospho-ALK (Tyr672, Tyr1278) Polyclonal Antibody detects endogenous levels of ALK only when phosphorylated at Tyr672, Tyr1278.

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3 ft. half of ALK, derived from chromosome 2, is fused to the 5 ft. portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
Specifications

Specifications

Phospho-ALK (Tyr672, Tyr1278)
Polyclonal
Unconjugated
ALK
Liquid
ALK
A synthesized peptide derived from human LTK/ALK (Phospho-Tyr672/Tyr1278)
Affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q9UM73
ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246; CD246 antigen; mutant anaplastic lymphoma kinase; NBLST3; TFG/ALK
Rabbit
IgG
100 μL
-20°C
Primary
238
SDS
Documents
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