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Phospho-ASK1 (Ser83) Rabbit anti-Human, Mouse, Rat, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Invitrogen MA528020

Catalog No. PIMA528020


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Description

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
Specifications

Specifications

Phospho-ASK1 (Ser83)
Recombinant Monoclonal
0.5 mg/ml
PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
O35099, Q99683
MAP3K5
A synthetic phospho-peptide corresponding to residues surrounding Ser83 of human phospho Ask1
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Flow Cytometry, Western Blot
Ask1S83-G4
Unconjugated
MAP3K5
Liquid
Rabbit
IgG1, kappa
200 μl
4° C
Primary
26408, 365057, 4217
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