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Phospho-ATF2 (Thr71) Rabbit anti-Human, Mouse, FITC, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Invitrogen MA527991

Catalog No. PIMA527991


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Description

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2.
Specifications

Specifications

Phospho-ATF2 (Thr71)
Recombinant Monoclonal
FITC
ATF2
Liquid
Rabbit
IgG1, kappa
100 tests
4° C
Primary
11909, 1386
Flow Cytometry
ATF2T71-G3
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
P15336, P16951
ATF2
A synthetic phospho-peptide corresponding to residues surrounding Thr71 of human phospho ATF2
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse
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