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Phospho-BTK (Tyr223) Rabbit anti-Human, Mouse, FITC, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Invitrogen MA528076

Catalog No. PIMA528076


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Description

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

BTK (Bruton ft.s tyrosine kinase or tyrosine-protein kinase BTK) was initially identified as a member of the src family for protein-tyrosine kinases that was involved in X-linked a-gamma-globulinaemia, and has since been shown to be involved in a number of signaling pathways in hemapoietic lineage. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.
Specifications

Specifications

Phospho-BTK (Tyr223)
Recombinant Monoclonal
FITC
BTK
Liquid
Rabbit
IgG1, kappa
100 tests
4° C
Primary
12229, 695
Flow Cytometry
BtkY223-B4
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
P35991, Q06187
BTK
A synthetic phospho-peptide corresponding to residues surrounding Tyr223 of human phospho Btk
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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