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Phospho-c-Met (Tyr1234, Tyr1235) Rabbit anti-Human|Mouse|Rat, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS3272R

Catalog No. 50-198-5267


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Description

Description

MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
Specifications

Specifications

Phospho-c-Met (Tyr1234, Tyr1235)
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
MET
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
17295, 24553, 4233
MET
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P08581, P16056, P97523
AI838057; AUTS9; bHLHe59; CG1705; CG1705 gene product from transcript CG1705-RB; CG1705-PA; CG1705-PB; cMet; c-Met; DFNB97; Dmel\CG1705; Dmel_CG1705; DmMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF; HGF receptor; HGF receptor c-Met; HGF/SF receptor; HGFR; HGF-SF receptor; juvenile hormone resistance; MET; met proto-oncogene; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET proto-oncogene, receptor tyrosine kinase; Met/Met1; methoprene tolerant; Methoprene-tolerant; Methoprene-tolerant protein; Met-PA; Met-PB; Mett; oncogene MET; Par4; Proto-oncogene c-Met; RCCP2; resistance (1) juvenile H; resistance to juvenile hormone; Rst(1)JH; sc MET; Scatter factor receptor; SF receptor; soluble c met; Tyrosine-protein kinase Met
KLH conjugated synthetic phosphopeptide derived from human c-Met around the phosphorylation site of Tyr1234/1235.
Protein A
RUO
Antibody
Polyclonal
Human, Mouse, Rat
SDS
Documents
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