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Phospho-c-Raf (Ser259) Rabbit anti-Human, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Thermo Scientific MA533195

Catalog No. PIMA533195


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Description

Description

The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK (Marshall, 1996). Previous studies have shown that phosphorylation is required for Raf-1 activation (Dhillon and Kolch, 2002; Chon et al, 2003). Recent work has demonstrated that phosphorylation also regulates the downregulation of Raf (Dougherty et al, 2005) with two sites participating Ser 301 and Ser 642.
Specifications

Specifications

Phospho-c-Raf (Ser259)
Recombinant Monoclonal
Unconjugated
RAF1
Liquid
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5894
ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin)
1.25 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P04049
RAF1
A synthesized peptide derived from human Phospho-RAF1 (S259)
Protein G
RUO
Antibody
Monoclonal
Human
SDS
Documents
Product Certifications
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