Phospho-c-Raf (Ser471) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA512767

Catalog No. PIPA512767

Description

This antibody is predicted to react with bovine, chicken, mouse, rat and Xenopus based on sequence homology.

Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.

Specifications

• Antigen: Phospho-c-Raf (Ser471)
• Classification: Polyclonal
• Gene: RAF1
• Gene Alias: RAF proto-oncogene serine/threonine-protein kinase; Raf-1; C-RAF; cRaf; RAF1; RAF;
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5894
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Dot Blot, Immunocytochemistry, Immunofluorescence
• Conjugate: Unconjugated
• Gene Accession No.: P04049
• Gene Symbols: RAF1
• Immunogen: KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S471 of human RAF1
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG