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Phospho-Cardiac Troponin I (Ser22, Ser23) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540251

Catalog No. PA540251


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Specifications

Specifications

Phospho-Cardiac Troponin I (Ser22, Ser23)
Polyclonal
Unconjugated
TNNI3
Liquid
TNNI3
Synthesized peptide derived from human Troponin I-C around the phosphorylation site of S22/S23.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
P19429
TNNI3; TNNC1; Troponin I; cardiac muscle; Cardiac troponin I
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7137
Documents
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