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Phospho-Chk2 (T68) Rabbit anti-Human, Clone: 1238H, R&D Systems™

Recombinant Monoclonal Antibody

$125.35 - $329.00

Specifications

Antigen Chk2
Formulation Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with Sodium Azide
Format Purified
Clone 1238H
Applications Immunocytochemistry, Western Blot
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MAB1626SP View Documents R&D Systems
MAB1626SP
25 ug Each for $125.35
Add to cart
 
MAB1626100 View Documents R&D Systems
MAB1626100
100 ug Each for $329.00
Add to cart
 
Description

Description

Serine/threonine-protein kinase Chk2 (CHEK2) is a 65kDa member of Serine/threonine-protein kinase family of proteins. Chk2 regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Chk2 is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks.Existence of multiple splice variants of Chk2 is predicted. Human Chk2 shares 86% aa sequence identity with mouse Chk2.
Specifications

Specifications

Chk2
Purified
Immunocytochemistry, Western Blot
Rabbit
Protein A or G purified from cell culture supernatant
RUO
Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with Sodium Azide
1238H
Unconjugated
IgG
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
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