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Phospho-CREB (Thr100) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540171

Catalog No. PA540171


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.
Specifications

Specifications

Phospho-CREB (Thr100)
Polyclonal
Unconjugated
CREB1
Liquid
CREB1
Peptide sequence around phosphorylation site of threonine 100 (S-G-T(p)-Q-I) derived from Human CREB.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P16220
cAMP responsive element binding protein 1; cAMP-response element binding protein; CREB-1; CREB1
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1385
Documents
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