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Phospho-Cyclin D2 (Thr280) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540166

Catalog No. PA540166


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.
Specifications

Specifications

Phospho-Cyclin D2 (Thr280)
Polyclonal
Unconjugated
CCND2
Liquid
CCND2
Peptide sequence around phosphorylation site of threonine 280 (A-S-T(p)-P-T) derived from Human Cyclin D2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P30279
cyclin D2; G1/S-specific cyclin D2
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
894
Documents
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