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Phospho-DNMT1 (Tyr399) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540186

Catalog No. PA540186


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Description

Description

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintece of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2F-binding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells.
Specifications

Specifications

Phospho-DNMT1 (Tyr399)
Polyclonal
Unconjugated
DNMT1
Liquid
DNMT1
Synthesized peptide derived from human Dnmt1 around phosphorylation site of Y399.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P26358
DNMT1; AIM; DNMT; MCMT; CXXC9; HSN1E; FLJ16293; MGC104992
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1786
Documents
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