Invitrogen™ Phospho-EphB1/EphB3/EphB4 (Tyr778, Tyr792, Tyr774) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105950

Catalog No. PIPA5105950

Description

Antibody detects endogenous levels of EPH B1/3/4 only when phosphorylated at Tyr778/792/774.

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

Specifications

• Antigen: Phospho-EphB1/EphB3/EphB4 (Tyr778, Tyr792, Tyr774)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EPHB1
• Gene Alias: 9330129L11; AI042935; AW456895; AW488255; C130099E04Rik; Cek10; Cek6; Developmental kinase 2; developmental kinase 5; EK2; EK6; Elk; Elkh; ELK-related protein tyrosine kinase; Embryonic kinase 2; ENSMUSG00000074119; EPH receptor B1; Eph receptor B2 (ELK-related protein tyrosine kinase); Eph receptor B3; Eph receptor B4; eph tyrosine kinase 2; Ephb1; Ephb2; EPHB3; Ephb4; EPH-like kinase 2; EPH-like kinase 6; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; ephrin receptor EphB4; ephrin type-B receptor 1; Ephrin type-B receptor 3; ephrin type-B receptor 4; EPHT2; Epth2; Erk; ETK2; HEK2; Hek6; Hepatoma transmembrane kinase; HTK; human embryo kinase 2; MDK2; mDK-2; Mdk5; mDK-5; Myk1; NET; Neuronally-expressed EPH-related tyrosine kinase; Sek4; soluble EPHB1 variant 1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyro11; TYRO6; Tyrosine kinase MYK-1; tyrosine-protein kinase receptor EPH-2; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase receptor SEK-4; Tyrosine-protein kinase TYRO11; tyrosine-protein kinase TYRO6
• Host Species: Rabbit
• Purification Method: Sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13845, 13846, 2047, 2049, 2050, 24338, 270190, 287989, 686310
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P09759, P54753, P54754, P54760, P54761, P54762, Q8CBF3
• Gene Symbols: EPHB1, EPHB3, EPHB4
• Immunogen: A synthesized peptide derived from human EPHB1(Accession P54762), corresponding to amino acid residues around phosphorylated Tyr778.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG