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Phospho-hnRNP K (Ser216) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540174

Catalog No. PA540174


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction By similarity. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Specifications

Specifications

Phospho-hnRNP K (Ser216)
Polyclonal
Unconjugated
HNRNPK
Liquid
HNRNPK
Peptide sequence around phosphorylation site of serine 216 (S-E-S(p)-P-I) derived from Human hnRNP K.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P61978
Heterogeneous nuclear ribonucleoprotein K,hnRNP K,Transformation up-regulated nuclear protein, TUNP
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3190
Documents
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