Phospho-hnRNP K (Ser216) Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA540174
This antibody is predicted to react with mouse and rat based on sequence homology.One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction By similarity. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
|Phospho-hnRNP K (Ser216)|
|Peptide sequence around phosphorylation site of serine 216 (S-E-S(p)-P-I) derived from Human hnRNP K.|
|Antigen affinity chromatography|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.4|
|Heterogeneous nuclear ribonucleoprotein K,hnRNP K,Transformation up-regulated nuclear protein, TUNP|
|-20° C, Avoid Freeze/Thaw Cycles|
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