Phospho-Jak1 (Tyr1034, Tyr1035) Rabbit anti-Human|Mouse|Rat, Polyclonal, Bioss
Rabbit Polyclonal Antibody
Manufacturer: Bioss BS3238R
DescriptionJAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
|Phospho-Jak1 (Tyr1034, Tyr1035)|
|Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|16451, 3716, 84598|
|PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH|
|AA960307; BAP004; C130039L05Rik; EC 22.214.171.124; JAK1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1|
|KLH conjugated synthetic phosphopeptide derived from human Jak1 around the phosphorylation site of Tyr1034 + Tyr1035.|
|Human, Mouse, Rat|
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