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Phospho-Jak1 (Tyr1034, Tyr1035) Rabbit anti-Human|Mouse|Rat, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS3238R

Catalog No. 50-198-5242


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Description

Description

JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
Specifications

Specifications

Phospho-Jak1 (Tyr1034, Tyr1035)
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
JAK1
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
16451, 3716, 84598
JAK1
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P23458, P52332
AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; JAK1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1
KLH conjugated synthetic phosphopeptide derived from human Jak1 around the phosphorylation site of Tyr1034 + Tyr1035.
Protein A
RUO
Antibody
Polyclonal
Human, Mouse, Rat
SDS
Documents
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