Invitrogen™ Phospho-Kir6.2 (Thr224) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA540157

Catalog No. PA540157

Description

This antibody is predicted to react with mouse based on sequence homology.

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Specifications

• Antigen: Phospho-Kir6.2 (Thr224)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kcnj11
• Gene Alias: AI842722; ATP-sensitive inward rectifier potassium channel 11; AW491124; beta-cell inward rectifier subunit; BIR; HHF2; IKATP; Inward rectifier K(+) channel Kir6.2; inwardly rectifying potassium channel KIR6.2; IRK11; KATP; KATP channel; KCNJ11; Kir6.2; mBIR; MGC133230; MODY13; PHHI; potassium channel inwardly rectifing subfamily J member 11; potassium channel, inwardly rectifying subfamily J member 11; potassium channel, inwardly rectifying subfamily J, member 11; potassium inwardly rectifying channel, subfamily J, member 11; potassium inwardly-rectifying channel subfamily J member 11; potassium inwardly-rectifying channel, subfamily J, member 11; potassium voltage-gated channel subfamily J member 11; TNDM3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16514, 3767
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q14654, Q61743
• Gene Symbols: Kcnj11
• Immunogen: Peptide sequence around phosphorylation site of threonine 224 (K-T-TP-S-P) derived from Human Kir6.2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG