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Phospho-Ku70 (Ser5) Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540247

Catalog No. PA540247


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Description

Description

This antibody is predicted to react with human and mouse based on sequence homology.

Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3 ft.-5 ft. direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5 ft.-deoxyribose-5-phosphate lyase (5 ft.-dRP lyase), by catalyzing the beta-elimination of the 5 ft. deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5 ft.-dRP lyase activity allows to  ft.clean ft. the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.
Specifications

Specifications

Phospho-Ku70 (Ser5)
Polyclonal
Unconjugated
XRCC6
Liquid
XRCC6
Synthesized peptide derived from human Ku-70 around the phosphorylation site of S5.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
P12956
XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5′-deoxyribose-5-phosphate lyase Ku70; 5′-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
25019, 2547
Documents
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