Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Phospho-Leptin Receptor (Tyr1141) Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA564638

Catalog No. PIPA564638


Add to cart

Description

Description

Phospho-Leptin Receptor (Tyr1141) Polyclonal Antibody detects endogenous levels of Leptin Receptor only when phosphorylated at Tyr1141.

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.
Specifications

Specifications

Phospho-Leptin Receptor (Tyr1141)
Polyclonal
Unconjugated
LEPR
Liquid
LEPR
A synthesized peptide derived from human Leptin Receptor (Phospho-Tyr1141)
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P48357, P48356
HuB219.2
Rabbit
IgG
100 μL
-20°C
Primary
16847, 3953
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit