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Phospho-Lyn (Tyr508) Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540240

Catalog No. PA540240


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide.
Specifications

Specifications

Phospho-Lyn (Tyr508)
Polyclonal
Unconjugated
LYN
Liquid
LYN
Synthesized peptide derived from human Lyn around the phosphorylation site of Y508.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
P07948, P25911
LYN; JTK8; Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
17096, 4067
Documents
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