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Phospho-p53 (Ser46) Mouse anti-Human, Clone: GT1018, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527788

Catalog No. PIMA527788


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Description

Description

Positive Control: 293T, 293T (0.5 µM doxorubicin treatment for 24 hr) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent. Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory.
Specifications

Specifications

Phospho-p53 (Ser46)
Monoclonal
1 mg/ml
PBS with no preservative
P04637
TP53
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of p53 (phospho Ser46). The exact sequence is proprietary.
Protein A
RUO
Antibody
Monoclonal
Human
Immunocytochemistry, Immunofluorescence, Western Blot
GT1018
Unconjugated
TP53
Liquid
Mouse
IgG2a
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
7157
Documents
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