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Phospho-p70 S6 Kinase (Ser418) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA512782
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This antibody is predicted to react with bovine, mouse, rat and rabbit based on sequence homology.The p70 S6 kinase (p70 Ribosomal Protein S6 Kinase, p70S6K) is a 70 kDa member of the ribosomal S6 kinase (RSK) family of serine/threonine kinases. p70 S6 kinase is predomitly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.
|Phospho-p70 S6 Kinase (Ser418)|
|PS6K, S6K, S6K1, STK14A, p70(S6K)-alpha, p70-S6K, p70-alpha|
|Antigen Affinity Chromatography, Protein A|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S418 of human RPS6KB1|
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