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Phospho-PAK4/6/7 (Ser474, Ser602, Ser560) Rabbit anti-Human, Mouse, Rat, Unconjugated, Clone: ARC1596, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535881

Catalog No. PIMA535881


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Description

Description

PAK4 is highly expressed in prostate, testis and colon. PAK4 interacts tightly with GTP-bound but not GDP-bound CDC42 and weakly with RAC. PAK4 phosphorylates and autophosphorylates and also activates the JNK pathway. PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP and the CRIB motif is essential for this interaction. PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
Specifications

Specifications

Phospho-PAK4/6/7 (Ser474, Ser602, Ser560)
ARC1596
PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
D4A280, O96013, Q3ULB5, Q8BTW9, Q8C015, Q9NQU5, Q9P286
2900083L08Rik; 4732456M09; 5730488L07Rik; 6430627N20; AW555722; Kiaa1142; KIAA1264; mKIAA1142; p21-activated kinase 4; p21-activated kinase 5; p21-activated kinase 6; p21-activated kinase 7; Pak4; PAK-4; PAK5; PAK-5; Pak6; PAK-6; PAK7; PAK-7; Serine/threonine-protein kinase PAK 4; Serine/threonine-protein kinase PAK 5; Serine/threonine-protein kinase PAK 6
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
10298, 214230, 241656, 292756, 296078, 311450, 56924, 57144, 70584
Western Blot
Unconjugated
Pak4
Liquid
Pak4, PAK5, PAK6, Pak7
A phospho specific peptide corresponding to residues surrounding S474 of human PAK4
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Rat
SDS
Documents
Product Certifications
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