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Phospho-PDHA1 (Ser293) Rabbit anti-Human, Mouse, Rat, Unconjugated, Clone: ARC1567, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535866

Catalog No. PIMA535866


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Description

Description

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

Phospho-PDHA1 (Ser293)
ARC1567
PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
P08559, P26284, P35486
BOS_26312; PDHA; PDHA1; Pdha-1; PDHAD; PDHCE1A; PDHE1-A type I; PHE1A; Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
18597, 29554, 5160
Western Blot
Unconjugated
PDHA1
Liquid
PDHA1
A phospho specific peptide corresponding to residues surrounding S293 of human PDHA1
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Rat
SDS
Documents
Product Certifications
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