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Phospho-PI3K p85/p55 (Tyr458, Tyr199) Rabbit anti-Human, Mouse, PE, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Invitrogen MA528027

Catalog No. PIMA528027


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Description

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Phosphoinositide 3-kinase (PI3K, phospho PI3K) Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phospho PI3K is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. During insulin stimulation, it also binds to IRS-1. Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival.
Specifications

Specifications

Phospho-PI3K p85/p55 (Tyr458, Tyr199)
Recombinant Monoclonal
PE
PIK3R1
Liquid
Rabbit
IgG1, kappa
100 tests
4° C
Primary
18708, 5295
Flow Cytometry
PI3KY458-1A11
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
P26450, P27986
PIK3R1
A synthetic phospho-peptide corresponding to residues surrounding Tyr458 of human phospho PI3K p85
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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