Phospho-RAD17 (Ser656) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA585713

Catalog No. PIPA585713

Description

Keep as concentrated solution. Positive Control: 293T (100 uM etoposide treatment for 2 hrs). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Rad17 is essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. It has a weak ATPase activity required for binding to chromatin. Rad17 also participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.

Specifications

• Antigen: Phospho-RAD17 (Ser656)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rad17
• Gene Alias: CCYC, cell cycle checkpoint protein (RAD17), cell cycle checkpoint protein RAD17, DNA damage checkpoint control protein RAD17, DNA repair exonuclease RAD17, FLJ41520, hRad17, MmRad24, R24L, RAD1 homolog, RAD17, RAD17 (Ser647), RAD17 checkpoint clamp loader component, RAD17 homolog, RAD17 homolog (S. pombe), Rad17 like protein, Rad17-like protein, Rad17p, RAD17SP, RAD24, RF-C activator 1 homolog, RF-C/activator 1 homolog, YOR368W
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5884
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Western Blot
• Concentration: 2.25 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300, pH 7
• Gene Accession No.: O75943
• Gene Symbols: Rad17
• Immunogen: Carrier-protein conjugated synthetic peptide corresponding to residues around human Rad17 (phospho Ser656).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov