Phospho-RAD17 (Ser656) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA585713

Catalog No. PIPA585713

Description

Keep as concentrated solution. Positive Control: 293T (100 uM etoposide treatment for 2 hrs). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Rad17 is essential for sustained cell growth, maintece of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. It has a weak ATPase activity required for binding to chromatin. Rad17 also participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.

Specifications

• Antigen: Phospho-RAD17 (Ser656)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RAD17
• Gene Alias: Rad17 (pS656) Antibody; R24L Antibody; Rad17 phospho Antibody; RAD24 Antibody; RAD17SP Antibody; phospho Rad17 (pSer656) Antibody; Rad17 (phospho S656) Antibody; phospho Rad17 (S656) Antibody; phospho Ser656 Rad17 Antibody; phospho S656 Rad17 Antibody; Rad17 (phospho Ser656) Antibody; Rad17 phospho Ser656 Antibody; phospho Rad17 (pS656) Antibody; phospho Rad17 Antibody; Rad17 (pSer656) Antibody; HRAD17 Antibody; RAD17 homolog (S. pombe) Antibody; RAD17 Antibody; CCYC Antibody; Rad17 phospho S656 Antibody
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5884
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.25 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: O75943
• Gene Symbols: RAD17
• Immunogen: Carrier-protein conjugated synthetic peptide corresponding to residues around human Rad17 (phospho Ser656).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG