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Phospho-RNA pol II CTD (Ser7) Rat anti-Human, Clone: 4E12, Active Motif™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

$135.30 - $546.00

Specifications

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen Phospho-RNA pol II CTD (Ser7)
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3131 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61088
10 μg
Each for $135.30
Add to cart
 
50-199-3130 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
61087
100 μg
Each for $546.00
Add to cart
 
Description

Description

DNA-directed RNA polymerase II subunit RPB1 (POLR1A) is a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR1A is the largest subunit and is a catalytic component of RNA polymerase II which synthesizes mRNA precurors and many functional non-coding RNAs. It also forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft, and the jaws that are though to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic stie and is through to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II's largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination, and mRNA processing. Regulation of gene expression levels depends on the balance between methylation and acetylation levelts of the CTD-lysines.
Specifications

Specifications

Monoclonal
Primary
Phospho-RNA pol II CTD (Ser7)
Unconjugated
SDS
Product Certifications
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