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Phospho-SIK1 (Thr182) Rabbit anti-Human, Rat, Polyclonal, Invitrogen™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA564610

Catalog No. PIPA564610


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Description

Description

Phospho-SIK1 (Thr182) Polyclonal Antibody detects endogenous levels of SIK1 only when phosphorylated at Thr182.

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Specifications

Specifications

Phospho-SIK1 (Thr182)
Polyclonal
Unconjugated
SIK1
Liquid
SIK1
A synthesized peptide derived from human SIK (Phospho-Thr182)
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P57059, Q9R1U5
SIK, SNF1LK
Rabbit
IgG
100 μL
-20°C
Primary
150094, 59329
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