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Phospho-SMC1 (Ser966) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540249

Catalog No. PA540249


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Specifications

Specifications

Phospho-SMC1 (Ser966)
Polyclonal
Unconjugated
SMC1A
Liquid
SMC1A
Synthesized peptide derived from human SMC1 around the phosphorylation site of S966.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Q14683
SMC1A; DXS423E; KIAA0178; SB1.8; SMC1; SMC1L1; Structural maintece of chromosomes protein 1A; SMC protein 1A; SMC-1-alpha; SMC-1A; Sb1.8
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8243
Documents
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