Phospho-STAT1 (Ser727) Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-4082	Active Motif 39634	10 μL
50-199-4081	Active Motif 39633	200 μL

Description

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

Specifications

• Antigen: Phospho-STAT1 (Ser727)
• Applications: Dot Blot, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P42224
• Gene ID (Entrez): 6772
• Immunogen: This STAT1 phospho Ser727 antibody was raised against a synthetic peptide containing phospho-serine 727 of human STAT1.
• Primary or Secondary: Primary
• Product Type: Antibody

• Concentration: Conc. Not Determined
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: whole serum with 30% glycerol and 0.035% sodium azide; pH
• Gene Alias: 2010005J02Rik; AA408197; BOS_1917; CANDF7; DD6G4-4; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF-3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta; OTTHUMP00000165046; OTTHUMP00000205845; Signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1-like; signal transducer and activator of transcription-1; STAT; STAT1; STAT91; transcription factor ISGF-3; Transcription factor ISGF-3 components p91/p84
• Gene Symbols: STAT1
• Isotype: IgG
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: STAT1