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Phospho-TPPP (Ser18) Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA564724

Catalog No. PIPA564724


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Description

Description

Phospho-TPPP (Ser18) Polyclonal Antibody detects endogenous levels of TPPP only when phosphorylated at Ser18.

Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis and vesicle transport. TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm. TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. TPPP overexpression prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope. TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
Specifications

Specifications

Phospho-TPPP (Ser18)
Polyclonal
Unconjugated
TPPP
Liquid
TPPP
A synthesized peptide derived from human TPPP (Phospho-Ser18)
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
O94811, Q7TQD2
TPPP1
Rabbit
IgG
100 μL
-20°C
Primary
11076, 361466, 72948
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