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Phospho-Transferrin Receptor (Ser24) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540261

Catalog No. PA540261


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Description

Description

This antibody is predicted to react with mouse based on sequence homology.

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Specifications

Specifications

Phospho-Transferrin Receptor (Ser24)
Polyclonal
Unconjugated
TFRC
Liquid
TFRC
Synthesized peptide derived from human CD71 around the phosphorylation site of S24.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
P02786
TFRC; Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD antigen CD71
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7037
Documents
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