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Phospho-TrkA (Tyr701) Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540161

Catalog No. PA540161


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

TrkA (tropomyosin receptor kinase A) encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
Specifications

Specifications

Phospho-TrkA (Tyr701)
Polyclonal
Unconjugated
NTRK1
Liquid
NTRK1
Peptide sequence around phosphorylation site of tyrosine 701 (I-L-Y(p)-R-K) derived from Human Trk A.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P04629, Q3UFB7
EC 2.7.10.1; High affinity nerve growth factor receptor precursor; kinase TrkA; NTRK1; p140-TrkA; Slow nerve growth factor receptor; TRK; Trk-A; TRK1 transforming tyrosine kinase protein; TRKA
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
18211, 4914
Documents
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